Pharmacological Denervation and Glaucoma: A Clinical Trial by Ph.F.J. Hoyng

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By Ph.F.J. Hoyng

Glaucoma simplex or open perspective glaucoma is a sluggish, revolutionary disorder with an insidious direction which can result in blindness. in line with our con­ transitority country of data, the ailment starts with a reduced outflow of aqueous humor. This leads, occasionally after a interval of diminished aqueous humor construction as a result of a suggestions mechanism, to a rise in intra­ ocular strain (lOP). An increased lOP can ultimately result in optic nerve harm, which manifests itself morphologically as glaucomatous papillary excavation and functionally within the improvement of a visible box disorder. The vintage triad of increased lOP, papillary excavation and visible box disorder, on which the prognosis of glaucoma used to be additionally dependent in prior instances, is then pre­ despatched. To this may now in basic terms be further that tonography frequently indicates a de­ crease in aqueous humor outflow and that gonioscopy needs to display an open attitude. at the foundation of statistical findings, Goldmann has calculated that there is an period of so long as 18 years among the preliminary elevate in lOP and the advance of sight view defects. This perspective (which has been proven in perform) that the onset of the affliction should be demon­ strated through size of the lOP has brought a brand new point into the dialogue round glaucoma, particularly, the idea that of ocular high blood pressure. this means easily that there's an (statistically) increased intraocular pres­ certain, although the optic nerve would possibly not (yet) be damaged.

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Additional info for Pharmacological Denervation and Glaucoma: A Clinical Trial Report with Guanethidine and Adrenaline in One Eye Drop

Sample text

Trendelenburg (1963, 1966) summarized the pharmacological differences as follows: the supersensitivity induced by decentralization is relatively moderate and suspectible to the influence of directly and indirectly acting agonists of the transmitter. Decentralization does not result in depletion in the distal axons and the supersensitivity is independent of the degree of depletion; the supersensitivity brought about by denervation is the result of a number of mutually interactive factors; these are the liberation of the transmitter, the block of its reabsorption and the depletion of the transmitter in the distal axon.

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