Criteria (Dose/Effect Relationships) for Organochlorine by M. Mercier (Auth.)

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By M. Mercier (Auth.)

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4 χ 10 mm Hg at 20 C. The solubility in water at room temperature is 10 ppm. It is slightly soluble in petroleum oils, soluble in acetone and aromatic and chlorina­ ted hydrocarbons. Unless otherwise stated this section uses the name lindane to describe gamma-HCH. It is stable to air, light, heat and carbon dioxide. It is not attacked by strong acids but is dechlorinated by alkali. 43 44 USES 1, 2, 3, 4, 5, 6-hexachlorocyclohexane is a persistent stomach poison and contact insecticide with some fumigant action, the activity of which is determined by the content of the gamma isomer.

1949). 25 Effects in other species have been reported. , 1973). Residues of organochlorine insecticides have been implicated in the declining reproductive capacity of several species of birds (Ratcliffe, 1967 ; Hickey and Anderson, 1968). , 1969). Japanese quails fed 200 ppm DDT in their diet at the start of the laying period produced hatchable eggs but there was a high rate of mortality among the young birds within a few days of hatching. Clear signs of neurotoxicity were noted (Judah, 1962).

HCH applied to the skin at a concentration of 3-5 %, had a skin sensitising effect in 47 out of the 112 cases. Chronic liver damage (cirrhosis and chronic hepatitis) has been reported, on the basis of liver biopsy, in 8 workers heavily expo­ sed to HCH or HCH/DDT mixtures for periods ranging from 5-13 years. As far as possible, other factors, such as alcoholism, were exclu­ ded as the cause of the cirrhosis (Schuttmann, 1968). (Mayersdorf and Israel , 1974). The study was carried out on 73 workers who were continually exposed to HCH and also to DDT and benzilan.

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