By Allen G. Rodrigo, Gerald H. Learn Jr.
Computational and Evolutionary research of HIV Molecular Sequences is for all researchers drawn to HIV learn, even those that merely have a nodding acquaintance with computational biology (or people who are accustomed to a few, yet now not all, facets of the field). HIV examine is uncommon in that it brings jointly scientists from quite a lot of disciplines: clinicians, pathologists, immunologists, epidemiologists, virologists, computational biologists, structural biologists, evolutionary biologists, statisticians and mathematicians. This ebook seeks to bridge the distance among those teams, in either material and terminology. concentrated principally on HIV genetic version, Computational and Evolutionary research of HIV Molecular Sequences covers such matters as sampling and processing sequences, inhabitants genetics, phylogenetics and drug pursuits.
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Extra resources for Computational and Evolutionary Analysis of HIV Molecular Sequences
Branch lengths in ML and ME trees were adjusted to the indicated scale bar, and MP trees were drawn arbitrarily to reflect the information content in a comparable scale. epidemic because they happen to be involved in an extensive transmission chain. In this scenario, the subtypes can be biologically equivalent even though they are genetically very different. The alternative explanation is that the subtypes had certain characteristics that allowed them to out-compete less fit viral variants. This pre-supposes biological differences between the subtypes.
5 kilobases of contiguous sequence from each; 6) the absence of any subsegment that can join established genotypes (no recombinants). The combination of these criteria forms a sound basis for establishing a new subtype. However, when attempting to classify a sequence as an established subtype, less strict criteria may be used, as long as this is made clear. For instance, if only the env V3 region (typically 300 bp) was used to classify a virus one might propose that the env V3 region belongs to a given subtype.
HIV-1 SUBTYPING Carla L. Kuiken* and Thomas Leitner*§ *Theoretical Biology and Biophysics Group, Los Alamos National Laboratory Los Alamos, NM 87545 USA § Department of Virology, Swedish Institute for Infectious Disease Control, 17182 Solna, Sweden 1. INTRODUCTION The family of human immunodeficiency viruses (HIV) consists of groups of clearly related but genetically distinct retroviruses. The most basic division is between the two distantly related types of viruses that cause AIDS in humans, human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2).