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Many alternative pathological stipulations are presently lower than research as healing goals of purines together with melanoma, cardiovascular stipulations, behavioural problems, irritation, immunoregulation, and neuroendocrine functionality. This publication attracts jointly study on all features of P2 purinoceptors and discusses their use in several healing components.
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Additional info for Ciba Foundation Symposium 198 - P2 Purinoceptors: Localization, Function and Transduction Mechanisms
Obviously, the radiolabelled ATP is going to bind only to a subclass of P2X receptors, but how do you know that it’s not binding to many other nucleotide-binding proteins, such as lunases and ATP synthases? Barnard: I can throw a little light on that. On rat brain membranes we have studied the binding of ATP derivatives (Simon et a1 1995) and Michel & Humphrey (1993) have looked at the binding of a,fi-methylene ATP. The binding of ATP to enzymes of brain membranes and so forth is definitely at a very much lower affinity and is also absolutely dependent on divalent cations (Bo et al 1992, Humphrey et a1 1995).
Barnard: I can throw a little light on that. On rat brain membranes we have studied the binding of ATP derivatives (Simon et a1 1995) and Michel & Humphrey (1993) have looked at the binding of a,fi-methylene ATP. The binding of ATP to enzymes of brain membranes and so forth is definitely at a very much lower affinity and is also absolutely dependent on divalent cations (Bo et al 1992, Humphrey et a1 1995). -methylene ATP which corresponds to a class of P2X receptors. The pharmacology of that latter binding is unmistakable: it shows the profile of the P2Y I receptor.
Prostaglandins 16:245-251 Di Virgilio F, Ferrari D , Munerati M et al 1995 The P2Z receptor and its regulation of macrophage function. In: Belardinelli L, Pelleg A (eds) Adenosine and adenine nucleotides: from molecular biology to integrative physiology. Kluwer Acad, Norwell, MA, p 329-335 Drury AN, Szent-Gyorgyi A 1929 The physiological activity of adenine compounds with special reference to their action upon the mammalian heart. J Physiol68:213-237 Dubyak G R 1991 Signal transduction by P2-purinergic receptors for extracellular ATP.