Autophagy by Daniel J. Klionsky

By Daniel J. Klionsky

Klionsky (life sciences, U. of Michigan, Ann Arbor) defines "autophagy" as "a strategy during which the mobilephone normally undergoes membrane rearrangement to sequester a component of cytoplasm, convey it to a degradative organelle and recycle the macromolecular components. He argues that, within the conventional view of organelles as mobile rubbish disposals, the continuing force towards homeostatis among phone loss of life and synthesis has been neglected. His creation additionally lists the hot nomenclature for 27 autophagy-related genes. In 22 different chapters, overseas members assessment autophagy in organisms from yeast to people and its roles in metabolism, getting older, melanoma and neuromuscular illnesses. a few photos are in colour.

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Sample text

Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy. J Cell Biol 1978; 78:152-167. 45. Mizushima N, Yamamoto A, Hatano M et al. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 2001; 152:657-667. 46. Kabeya Y, Mizushima N, Ueno T et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720-5728.

Tissue & Cell 1969; 1:103-154. 13. Cole S, Matter AM, Karnovsky MJ. Autophagic vacuoles in experimental atrophy. Exp Mol Pathol 1971; 14:158-175. 14. Novikoff AB, Shin W-Y. Endoplasmic reticulum and autophagy in rat hepatocytes. Proc Natl Acad Sci USA 1978; 75:5039-5042. 15. Frank AL, Christensen AK. Localization of acid phosphatase in lipofuscin granules and possible autophagic vacuoles in interstitial cells of the guinea pig testis. J Cell Biol 1968; 36:1-13. 16. Locke M, Sykes AK. The role of the Golgi complex in the isolation and digestion of organelles.

Eur J Biochem 1990; 190:63-69. 56. Ruud Larsen A-K, Møller MTN, Blankson H et al. Naringin-sensitive phosphorylation of plectin, a cytoskeletal crosslinking protein, in isolated rat hepatocytes. J Biol Chem 2002; 277:34826-34835. 57. Blankson H, Grotterød EM, Seglen PO. Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin. Cell Death Differ 2000; 7:739-746. 58. Doherty FJ, Wassell JA, Mayer RJ. A putative protein-sequestration site involving intermediate filaments for protein degradation by autophagy.

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